A structured pre-submission assessment of clinical research manuscripts. We classify the design and the claim, test whether your conclusions match your evidence, recompute statistics where the numbers allow, and return a severity-scored report grounded in your own quotes.
| 01 | Design / claim fit | Serious |
| 02 | Results / conclusion | Moderate |
| 03 | Statistical method | Serious |
| 04 | Reporting guideline | Mild |
| 05 | Numerical consistency | Critical |
| 06 | Clinical verdict | Moderate |
The publication loop is slow, statistical review is scarce, and small methodological errors are common — and costly. RigorMD finds them before a reviewer does.
Submission to publication runs from roughly 70 to 558 days across biomedical journals — and every revision or rejection round adds more. Catch the fatal flaw before a reviewer does.
Biostatistics expertise is scarce and gated — academic units are capacity-strained, and the NIH now requires a statistician on trial grants. Get a structured read without the queue.
In one audit of orthopaedic journals, 17% of papers had a statistical error that could change the conclusion. Our deterministic layer recomputes the numbers and reconciles every p-value.
Biomedical retractions have quadrupled in 20 years. The statistical and interpretive errors we flag are a preventable share — and one weak paper can shadow an entire group.
And because this is clinical research, the deepest reason is the simplest: a flawed statistic becomes flawed care. Cleaner evidence is better medicine.
Manuscript, tables, figures, supplement, cover letter, title page. PDF and DOCX. Confirm what's included.
We classify the study design and claim type, then two independent engines appraise across six domains.
Deterministic checks recompute p-values, intervals, and denominators. Every finding is traced to a quote.
A reconciled, severity-scored report — emailed when ready, stored in your private dashboard.
Full validation is not instant. Most reports return by email after processing; larger packages take longer.
Whether a causal, comparative, or equivalence claim is supported by the study design actually used.
Whether the abstract, results, and conclusions agree — without spin or reframed null findings.
Models, power, missing-data handling, and multiplicity, matched to the design and endpoints.
Design-specific reporting requirements, item by item, with the gaps named.
Whether numbers, denominators, p-values, intervals, tables, and text agree with one another.
What a clinician or editor can legitimately take from the manuscript as written.
Every serious or critical finding is grounded in a direct quote or a recomputed number — so you can verify it, not just trust it.
“The sleeve and bypass groups showed no significant difference in 30-day readmission (p = 0.04).”Table 3 · sleeve (n=212) vs bypass (n=198)
Catch methodological, statistical, and reporting problems before a journal — or a reviewer — catches them for you.
One consistent pre-submission review across trainees, faculty, and clinical research groups — with an aggregate view of where manuscripts fail.
A structured methods-and-statistics triage layer before external peer review. Decision support — never an automated decision.
Each manuscript is appraised independently by two engines and reconciled into a consensus — disagreement is surfaced, not hidden. A deterministic layer recomputes statistics where the reported numbers allow, so a flag is a calculation you can check. Findings quote the manuscript directly and state, for every serious or critical issue, the direction of bias and its clinical consequence.
And we are explicit about the limits: the report distinguishes checked and passed from not checkable from the submitted files. Without raw data, some questions can't be answered — and we say so.
Launch pricing. Every report is fully automated — two independent engines plus deterministic checks, with no human review and no queue. Volume and academic pricing available.
Upload your package, confirm what's included, and we'll return a severity-scored validation report.